hrp0086rfc15.8 | Late Breaking | ESPE2016

Replacement of Male Mini-Puberty

Papadimitriou Dimitrios T. , Chrysis Dionysios , Zoupanos Georgios , Nyktari Georgia , Liakou Eleni , Papadimitriou Anastasios

Background: Hormonal replacement in boys with congenital HH remains a challenge. Micropenis has been traditionally successfully treated with 3 monthly injections of testosterone enanthate before the age of 2, but when bilateral cryptorchidism coincides, surgery is required. But even after a successful surgery, the hypoplastic testes with the deficient proliferation of immature Sertoli cells, due mainly to the lack of the male mini-puberty in the neonatal period as well as the ...